Prof. Dr. Maria Elena Torres Padilla
Director of Biomedicine

Maria Elena Torres-Padilla  combines high resolution microscopy, single cell omics and cell biology approaches to uncover the origin of stem cells and the epigenetic principles that control cellular plasticity. Such insights will enable the generation of high-quality, fully reprogrammed stem cells, vital for the full implementation of regenerative medicine approaches in the clinic. 

 

Factsheet
Prof. Dr. Maria Elena Torres Padilla

Positions and Career

Since 2016
Director, Institute of Epigenetics & Stem Cells, Helmholtz Zentrum Munich
Professor, Chair of Stem Cell Biology at the Faculty of Biology, Ludwig-Maximilians-University Munich

2008-2016
Independent group leader at the IGBMC, Strasbourg
Director of Research INSERM (DR2) position obtained in the Concours de Recrutement 2012

2007-2008
CR1 INSERM position obtained in the Concours de Recrutement 2007

2006-2007
Post-doc , Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch

2002- 2006
Post-doc, The Wellcome Trust/CR UK Gurdon Institute of Cancer Research and Developmental Biology,  Cambridge, UK

2001
Visitor at the University of California, Riverside

1998- 2002
Ph. D. Thesis, Department of Molecular Biology, Institut Pasteur, Paris

1998
Senior Scientist, Cellular Physiology Institute, National University of Mexico

1997
Project for obtaining degree, Cellular Physiology Institute, National University of Mexico

1995-1997
Undergraduate student, Cellular Physiology Institute, National University of Mexico

1994-1995.
Undergraduate student, Department of Immunology,  Biomedical Research Institute. National University of Mexico

 

2008
Université Louis-Pasteur, Strasbourg,  Habilitation à Diriger des Recherches

2002
Institut Pasteur/University of Paris V. , Ph. D. degree (obtained with honors : Mention ‘Très honorable avec les Félicitations du Jury’)

1997
National University of Mexico (UNAM), Licenciatura Degree in Biology

 

2018
German Stem Cell Network Female Scientist Award

2015
Selected as Young Scientist by the World Economic Forum

2015
Elected EMBO Member

2014
Prix Fondation Université de Strasbourg-Cercle Gutenberg

2014
Prix de la Fondation Schlumberger pour l’Education et la Recherche

2011
EMBO Young Investigator

2011
Elected RISE1 Member of EpiGeneSys Network of Excellence                

2009
Prize Fondation pour la Recherche Médicale (FRM) Alsace

2006
Royal Society, Conference Award

1998
Gabino Barreda Award. Universidad Nacional Autonoma de México

1998
Canifarma Prize. Instituto Politecnico Nacional de México 

 

Selected Publications

Heterochromatin establishment during early mammalian development is regulated by pericentromeric RNA and characterized by non-repressive H3K9me3

Burton A, Brochard V, Galan C, Ruiz-Morales ER, Rovira Q, Rodriguez-Terrones D, Kruse K, Le Gras S, Udayakumar VS, Chin HG, Eid A, Liu X, Wang C, Gao S, Pradhan S, Vaquerizas JM, Beaujean N, Jenuwein T, Torres-Padilla ME.
Nature Cell Biology  22(7):767-778.

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Genome-lamina interactions are established de novo in the early mouse embryo

Borsos M*, Perricone SM*, Schauer T, Pontabry J, de Luca KL, de Vries SS, Ruiz-Morales ER, Torres-Padilla ME§ ‡,  Kind J §.  Nature 569:729-733.     

 * equal contribution; § co-corresponding authors; lead contact

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A molecular roadmap for the emergence of early-embryonic-like cells

Rodriguez-Terrones D, Gaume X, Ishiuchi T, Weiss A, Kopp A, Kruse K, Penning A, Vaquerizas JM, Brino L, Torres-Padilla ME.

Nature Genetics 50(1): 106-119.

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LINE-1 activation after fertilization regulates global chromatin accessibility in the early mouse embryo

Jachowicz J, Bing X, Pontabry J, Boskovic A, Rando O, Torres-Padilla ME. Nature Genetics49(10):1502-1510

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Early embryonic-like cells are induced by down-regulating replication-dependent chromatin assembly

Ishiuchi T, Enriquez-Gasca R, Mizutani E, Bošković A, Ziegler-Birling C, Rodriguez-Terrones D, Wakayama T, Vaquerizas JM, Torres-Padilla ME. Nature Structural & Molecular Biology22(9):662-71.

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Higher chromatin mobility supports totipotency and precedes pluripotency in vivo

Boskovic A, Eid A, Pontabry J, Ishiuchi T, Spiegelhalter C, Ram EVSR, Meshorer E, Torres-Padilla ME. Genes & Development28(10):1042-7.

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Chromatin signatures and retrotransposon profiling in mouse embryos reveal regulation of LINE-1 by RNA

Fadloun A, Le Gras S, Jost B, Ziegler-Birling C, Takahashi H, Gorab E, Carninci P, Torres-Padilla ME. Nature Structural & Molecular Biology20(3):332-8.

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Live visualization of chromatin dynamics using fluorescent TALEs

Miyanari Y, Ziegler-Birling C, Torres-Padilla ME. Nature Structural & Molecular Biology 20(11):1321-4.

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Heterochromatin formation in the mouse embryo requires critical residues of the histone variant H3.3

Santenard A, Ziegler-Birling C, Koch M, Tora L, Bannister AJ, Torres-Padilla ME. Nature Cell Biology12(9):853-62.

 

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