HPC Principal Investigators are outstanding scientists with a proven track record in their respective fields and the ambition to make a difference in biomedicine, harnessing engineering and informatics tools. They are interdisciplinary by nature, highly collaborative, and committed to drive a globally competitive research program.
HPC scientists work towards a comprehensive and systems-level understanding of human physiology to revolutionize future diagnostics and therapies.
Quantitative Cell Biology
Nicolas´lab is interested in the strategies that cells use to control gene expression levels and variability during differentiation.
3D Genome & Molecular Neurobiology
Boyan's team deciphers the genetic and epigenetic blueprints of brain development and evolution, thereby unravelling new paradigms at the interplay of transcription factors, chromatin topology and the control of gene expression in vivo.
Celia P. Martinez Jimenez
Celia's team applies single-cell approaches to interrogate molecular features as predictor of molecular age. The assessment of intra-organ cell-to-cell variability will instruct precision diagnostics and personalized treatments.
Bioengineering and Microfluidics
Matthias' team advances the microfluidic organ-on-chip technology to characterize biomolecules and their functional interactions on the single cell level and in the context of whole organs.
HPC scientists employ modern bioengineering principles and aim to develop new techniques and tools for trail-blazing applications in biological systems.
Next-Generation in vivo Imaging
Oliver's team combines targeted probe development and novel imaging setups to rapidly translate the technological advantages of SWIR into new imaging capabilities for both preclinical- and therapeutic applications.
The nanoProbe Lab
Jian’s team synthesizes novel classes of nanomaterials with unique chemical and optical properties. We aim to apply these materials towards the development of unconventional approaches to biological imaging and sensing.
The Cryoskeleton Lab
Marion’s team explores the diversity of actin structures involved in cell invasion and contractility using cryo-electron tomography. Her group aims to elucidate the structural principles governing actin functions across scales, and to provide an integrated view of the mechanisms of force generation by actin networks in cells.
Janna’s group is an interdisciplinary team of biologists and engineers investigating the structure-function relationships of the human airways and other tissues involved in fluid transport.
HPC scientists embrace information technologies to transform biomedical discovery and empower a revolution in healthcare.
Translational Genetics Group
Na Cai’s research group focuses on understanding the etiology of neuropsychiatric conditions, with a particular focus on Major Depressive Disorder (MDD).
Francesco Paolo Casale
Systems Genetics and Machine Learning
Paolo’s research group focuses on the development and application of machine learning and statistical approaches to advance our understanding of complex trait and disease biology.
Bastian's research group analyses complex biomedical data sets using multi-scale methods based on topological concepts.
Lara Urban’s research group focuses on the application of Molecular Biology and Artificial Intelligence (AI) in the context of planetary health, with a particular interest in the impact of environmental changes on human health.
Our New Building
The new HPC laboratory and office building, future home of up to 20 pioneer groups and management, is designed by wulf architekten (based in Stuttgart/Berlin, Germany) and scheduled to go into operation in 2023. Flexibility is one of the building’s hallmark, catering to the general concept of the HPC: teams that integrate various disciplines and research areas, a highly technology-driven research environment, and the continuous fluctuation of pioneer teams.